Monday, June 29, 2015

Sarah Rothstein of Nalas Engineering: Design a continuous flow process using batch lab data

This webinar from our 2014 series features a fine example of using modeling to get insight without committing resources.  Sarah Rothstein and her colleagues at Nalas Engineering used DynoChem to design a continuous process using batch experiments and found optimum operating conditions without running any experiments in the 'flow' system.

Invest 7 minutes to see what good users can do with our tools:

If you'd like instead to see the full version of Sarah's webinar, follow this link to DynoChem Resources.

Friday, June 19, 2015

DynoChem Spray Dryer model calculates thermodynamic Design Space

When planning to select or use a spray dryer in the lab or at larger scale, it's important to know the right operating conditions (feed rate, gas inlet temperature, pressure) to achieve potential critical quality attributes like residual moisture and gas outlet temperature.  You can map your dryer's operating space easily using the DynoChem spray dryer template, reducing your dependence on trial and error to find the right process conditions.

Results can be generated for any solvent system in a few minutes.  You can also fit the heat loss parameter (UA) to better characterize your dryer.  And fit the gas-liquid mass transfer parameter (kLa) if your system does not reach equilibrium.

Wednesday, June 10, 2015

June update adds models for genotoxic impurity formation and control, precipitation, PK/PD and more

One of the great things about using DynoChem is the regular update of the online library, delivering the latest and best models to all users instantly.

Blood pressure regulation in a specific patient using a 200mg daily dose.
In the June update:

  • We published a new guidance document for solvent swap distillation, a very popular DynoChem application. 
  • We added new models for sulfonate ester / genotoxic impurity formation (based on work using DynoChem by Dr Ed Delaney and a PQRI consortium)
  • We added new models for tangential flow filtration (TFF), precipitation and PK/PD calculations. 
  • We republished the DynoChem Validation document, illustrating the accuracy of each DynoChem model building statement. 
  • We updated our solvent properties shortlist, adding three solvents (1-propanol, isobutanol and trifluoroacetic acid) 
  • We updated a number of models to the new standard format.
To try them out, visit DynoChem Resources.

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