Friday, January 1, 2016

Use these links to get Advice, Guidance and Help as you apply our tools in 2016

Are you managing a team that works in process development and scale-up?  Or working at the coalface applying our tools on a regular basis?  Or perhaps you're a former DynoChem user whose modeling exploits have helped lead to rapid promotion :) and it's been a while since you last visited us?

Either way, you should find the following links interesting and useful as you start the new year of 2016.
  • For general advice on topics in process development and scale-up, use the 'advice' search string in DynoChem Resources, or click this link:  
  • One document that appears in this list has some new additions including a list of typical values for process parameters and a list of recommended text books for your department library.
  • To get a helicopter view and roadmap about how to apply our software in a specific area, search instead for 'guidance' or click
  • The solid-liquid separation guidance has been updated recently to help define how to set up a lab filtration rig, thanks to publications by customers such as BMS and Amgen:
Of course you can share all of these links with your team and colleagues by email and otherwise.

And we'd love to get both your and their feedback in due course so that we can improve our tools for the benefit the whole process development and scale-up community.

Monday, November 23, 2015

AIChE 2015; QbD, Awards, Reception; honoured to be made a Fellow

Readers of this blog (and members of the DynoChem community in general) will be aware that the AIChE Annual Meeting is an excellent place to learn about the current practicalities of implementing QbD.

The 2015 Annual meeting took place in Salt Lake City earlier this month and three of our team attended, Peter, Marion and myself (Joe).  We attended the pharma sessions mostly, plus a few process development, green chemistry and mixing sessions.  We were delighted to see so many customers presenting their DynoChem work and you can download a list of papers that referenced DynoChem here (Microsoft OneDrive) or here (Dropbox).  We also presented on some lab reactor characterisation work carried out with Pfizer and this will be presented as a DynoChem webinar in 2016 and the slides will be made available in DynoChem Resources.

We participated in the QbD Awards presentation, where the drug substance prize sponsored by our company (Scale-up Systems) went to Dr Dan Hallow of J&J (formerly BMS).

And we held a reception/party for our customers, which we run every few years, featuring news and previews of forthcoming tools and the DynoChem Jeopardy game, in which the categories this year were Chemistry, Chemical Engineering, Ireland and DynoChem.  A team assembled from Hovione (Portugal), Dow (Freeport, TX) and Eastman (Kingsport, TN) won the prize.  For more pictures, see our Facebook page.

Winners of DynoChem Jeopardy at AIChE 2015
Finally, I had the honour this year of being made a Fellow of AIChE, a distinction that I will wear with pride and also leverage to spread the word about the power of excellent chemical engineering in today's world.

Wednesday, October 14, 2015

Try attending our webinars on your phone / other mobile device

We record all of our webinars so that you can play them back if you miss them live or want a recap.  It's even better if you can attend live - then you have the chance to put your questions and comments to the speaker, live in the meeting chat pod.

With customers spread all over the world, our events may fall while you are having breakfast, or at the end of your day when you are back home.  That's why we've been investigating how well current mobile technology supports meeting attendance on your smartphone.  If that works, you can attend from pretty much anywhere you can get a phone signal.

The good news is that the Adobe Connect app is available for both iOS and Android platforms and this can be downloaded in the App Store or the Play Store.

Remember to register for the webinar in the usual way, so that our meeting facilitator is expecting you. Then at meeting time, open your mobile browser and navigate to our standard meetings page:; enter your name and click the Join Meeting button as if you were at your PC.  Your phone (iOS or Android) should take care of the rest, prompting you to open the Adobe Connect app and Request Entry.

Important:  Use your full name for identification purposes.

Once admitted to the meeting, you'll enjoy audio and the usual screens like this (all captures taken recently using an iPhone 5S):

Give this a try when you get a chance and let us know how it goes.

Friday, August 21, 2015

Use kinetic models to obtain conservative estimates of TMR (time to maximum rate)

Readers with an interest in process safety (isn't that everyone?) should be aware of some important limitations in the traditional method for obtaining TMR, the time to maximum rate, as referenced here, for example.

Wilfried Hoffmann, one of our principal consultants supporting users and an experienced former specialist in process safety at Pfizer, highlighted in his December 2014 DynoChem webinar how:

  1. the traditional approach to TMR using MTSR (maximum temperature reached as a result of adiabatic temperature rise of the desired reaction, after a cooling failure) ignores the kinetics of the desired reaction; that makes it simple, but potentially less accurate; this is understandable as when the method was developed, kinetics were less readily obtained
  2. the traditional method neglects the time to MTSR in calculating TMR and time to explosion
  3. the modern method uses kinetics to get the true TMR
  4. there are two extremes where the difference between traditional and modern methods is significant:
    • with a slow reaction, perhaps taking place at low temperature, it may take a long time to reach MTSR; in this case, traditional TMR < true TMR and the traditional method may be used safely; it overestimates risk
    • in situations where on the way to MTSR, there is a heat flow contribution from the undesired reaction, the adiabatic temperature rise will then be higher than MTSR and the true TMR will be shorter than the estimate using the traditional method.

You can watch a preview of Wilfried's discussion on YouTube.  You can also read more in his book chapter here.

Needless to say, we recommend that you use kinetic information to calculate TMR, so that you can make stronger safety statements.  If you have access to DynoChem and our online library, follow this link to find the main tools, step by step training and a nice customer case study by Siegfried.

Slide from Wilfried Hoffmann's webinar, illustrating response surfaces of true TMR, obtained from kinetic models of the desired and undesired reactions.

Thursday, August 20, 2015

Continuous improvement, with enhanced tools and guidance for PFR, CSTR and axial dispersion models

Readers will doubtless be aware of the momentum behind the move to continuous manufacturing of pharmaceuticals and the "Need for enhanced process understanding ...Availability of mechanistic models for all processing steps".  We frequently support customers either exploring or making the transition from batch to continuous and there are many case studies available showing how to use DynoChem in this context.

In the August update of our online library, we added new guidance documents on how to apply the platform tools in this area.  Separate documents address PFR, CSTR and PFRs with axial dispersion. We also enhanced each of the models and the training exercises that step you through an application.

For those who are interested in connecting models together in a flowsheet simulation, we set up a few examples illustrating how to do this and these are available to certified and power users on request from our support team.
Substrate concentration versus residence time for second order reaction with 5% excess.  Comparison of ideal PFR with tanks-in-series models representing different degrees of backmixing / axial dispersion.
We'd be glad to receive your feedback in due course on all of the above.

Wednesday, July 29, 2015

Kinetics from HPLC data - DynoChem guidance documents

HPLC area and area percent are some of the most commonly used data for reaction and impurity profiling and monitoring.  Customers collect these data all the time, whether working in the lab or the plant, in early or late phase development.  HPLC data are routinely used in regulatory filings and to ensure quality and compliance.

The good news for DynoChem users is that reaction kinetics may also be obtained from these data, when certain conditions are met.  Yes, there is some fine print, but not too much.  Armed with kinetics, you can run fewer, better experiments and save weeks or months of experiments and speculation.  (You might enjoy our playlist of short humorous videos on this very topic.)

In this and several other application areas, our team have recently written new 'Guidance Documents'. These follow a standard format and are short and to the point.  They provide a helicopter view and a roadmap for applying DynoChem in a specific application area.  Naturally the guidance document for reaction kinetics puts a lot of emphasis on HPLC data.  You can get the full story by following this link.

Contents page of the Reaction Modeling Guidance Document: click for step by step instructions.

Wednesday, July 8, 2015

Generate cocrystal ternary phase diagrams to support process design

We love to provide solutions that save customers time.  A good example arises in process and experimental design aimed at formation of cocrystals.

DynoChem already includes tools to support solvent selection for crystallization and these can indicate the effects of solvent choice on API ("A"), coformer ("B") and cocrystal ("AB") solubility, based on a handful of measurements in a few solvents.  We also provide templates for solution-mediated conversion between forms and drug product salt disproportionation in the presence of excipients.

For cocrystals, once solubilities are known, either by measurement or prediction, a DynoChem dynamic model can simulate in a few seconds the time-dependent equilibration of a large set of potential experiments, reducing the need for painstaking and slow lab experimentation.

Figure 1: Process scheme for simulating cocrystallization process; more solid phases may be included as needed

With this model, users can simulate the relative and total amounts of each of the (e.g. three) solid phases that may result from different starting conditions.  Those results can be plotted and summarized on a ternary phase diagram that summarizes the 'regions' of initial composition that lead selectively to formation of the desired phase.

Figure 2: Ternary phase diagram for an example cocrystal system, with a 1:1 cocrystal AB.

Contact if you'd like to discuss using these tools, or related applications to enantiomers and other systems.  Thanks to Dr Andrew Bird for providing the above illustrations.  

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