Thursday, August 20, 2015

Continuous improvement, with enhanced tools and guidance for PFR, CSTR and axial dispersion models

Readers will doubtless be aware of the momentum behind the move to continuous manufacturing of pharmaceuticals and the "Need for enhanced process understanding ...Availability of mechanistic models for all processing steps".  We frequently support customers either exploring or making the transition from batch to continuous and there are many case studies available showing how to use DynoChem in this context.

In the August update of our online library, we added new guidance documents on how to apply the platform tools in this area.  Separate documents address PFR, CSTR and PFRs with axial dispersion. We also enhanced each of the models and the training exercises that step you through an application.

For those who are interested in connecting models together in a flowsheet simulation, we set up a few examples illustrating how to do this and these are available to certified and power users on request from our support team.
Substrate concentration versus residence time for second order reaction with 5% excess.  Comparison of ideal PFR with tanks-in-series models representing different degrees of backmixing / axial dispersion.
We'd be glad to receive your feedback in due course on all of the above.

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