Monday, July 4, 2011

Another fine GSK example shows how to make synergistic use of Kinetics and DOE

Mark Hughes and colleagues from GSK recently wrote up another fine example of the synergistic use of kinetics and design of experiments.

To quote the authors, "The DoE studies gave us an idea of the risks ... the kinetic model had provided higher-yielding conditions".

For more details, see:
A Mechanistic Insight into a Simple C-N Bond Formation via SN2 Displacement: A Synergistic Kinetics and Design of Experiment Approach.
Vol. 14, No. 6, 2010 / Organic Process Research & Development
in DynoChem Resources and the ACS website.

No comments:

ShareThis small