Monday, June 6, 2011

Updated tools for size distribution modeling in DynoChem Resources

As the final part of a general update of our crystallization tools over the last year, we have just updated the utilities and models for size distribution calculations in DynoChem Resources.

The CSD/CLD tools are primarily for academic research purposes, rather than industrial application.  This is for two main reasons: i) most industrial problems can be solved without modeling the number balance/size distribution and ii) quantitative interpretation of measured size data for modeling remains a challenge (see e.g. reference 1).  Our models include options to 'calibrate' e.g. CLD data to close the mass balance.

You can find out more by reading the related Knowledge Base article.

For an example of mainstream application of DynoChem to industrial crystallization problems, see our Crystallization training exercise instead (Operation 5 in the manufacturing stage).

1. Zai Qun Yu, Pui Shan Chow and Reginald B. H. Tan, Interpretation of Focused Beam Reflectance Measurement (FBRM) Data via Simulated Crystallization, Organic Process Research & Development 2008, 12, 646–654,

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